Compare Weight-Loss Medications

Comparisons built only from facts that can be verified in FDA labeling: what each product contains, what the FDA approved it to treat, how it is given, and what its label says about safety.

What these comparisons do not do

We do not rank medications, declare a winner, or predict which will work better for you. Comparative effectiveness depends on the specific trials, populations, and endpoints involved and on individual factors a website cannot assess. Where a fact is not established in labeling, the table says so rather than guessing.

Wegovy vs. ZepboundWegovy and Zepbound are both FDA approved for chronic weight management and both are once-weekly injections — but they contain different active ingredients from different manufacturers, and Zepbound carries an additional FDA-approved indication for obstructive sleep apnea..FDA ApprovedFDA Approved Ozempic vs. WegovyOzempic and Wegovy contain the same active ingredient — semaglutide — from the same manufacturer, Novo Nordisk.FDA Approved for a Different IndicationFDA Approved Mounjaro vs. ZepboundMounjaro and Zepbound both contain tirzepatide and are both made by Eli Lilly.FDA Approved for a Different IndicationFDA Approved Semaglutide vs. TirzepatideSemaglutide and tirzepatide are the two active ingredients behind most of today’s prescription weight-management injections.FDA ApprovedFDA Approved

Not medical advice. WeightLossDrugsGuide is an independent educational publisher. We are not a pharmacy, a medical provider, or a telehealth clinic, and we do not provide personalized medical recommendations or dosing guidance. Information here summarizes official FDA labeling and other primary sources and may not reflect the most recent changes. Always talk with a licensed clinician about your own situation, and read the full prescribing information for any medication.