Managing retatrutide GI side effects (US): nausea, constipation, diarrhea playbook

Short answer

Most GI side effects improve with slower titration, smaller meals, hydration/electrolytes, and early constipation prevention. Red flags: inability to keep fluids down, severe persistent abdominal pain, fainting, blood in stool.

References

• Retatrutide phase 2 obesity trial (PubMed): https://pubmed.ncbi.nlm.nih.gov/37366315/
• MedlinePlus semaglutide injection: https://medlineplus.gov/druginfo/meds/a618008.html
• MedlinePlus tirzepatide injection: https://medlineplus.gov/druginfo/meds/a622044.html